"Mass Spectrometry Novel Technologies, Novel Modalities, and Novel Challenges"
New Tools to Reach Max Sensitivity & Selectivity; Advanced Applications in Column Chemistry and Separations Techniques; Problem Solving for Novel Modalities, Non-Liquid and Rare Matrices Method Development/Validation
Part 1: Novel Technologies
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Lecture 1:
Myths and Realities in the Use of HILIC to Replace Ion-Pairing and Hexafluoroisopranol (HFIP) for Oligonucleotides Bioanalysis: Does it really work? Is it possible to reproduce the published results? Is sensitivity still a limitation with HILIC approaches?
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Lecture 2:
Use of Aptamers as a Novel Reagent in Regulated Bioanalysis for Large Molecule Quantification by Hybrid Assays (IA-MS): Advantaged and Disadvantages in using Aptamers in Immunoaffinity enrichment
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Lecture 3:
EAD vs CID Fragmentation for Small Molecule and their Metabolites: Is EAD Technology going to replace CID or do we still need both?
Part 2: Novel Modalities & Novel Method Development/Validation Challenges
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Lectures 4, 5:
Novel/Advanced Strategies and Recent Advancements in ADC Bioanalysis by Mass Spectrometry
- Selecting the right Internal Standard - Lecture 4
- Method Development approaches for Biotransformation - Lecture 5
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Lectures 6, 7:
Novel/Advanced Strategies and Recent Advancements in RNAi and ASO Therapeutics Bioanalysis by Mass Spectrometry
- HRMS Method Development approaches for Metabolism/Biotransformation - Lecture 6
- Advantages of Hybridization Mass Spec vs “gold standard” Hybridization LBA - Lecture 7
Part 3: Problem Solving for Non-Liquid and Rare Matrices
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Lecture 8:
Peripheral Blood Mononuclear Cell (PBMC) by Mass Spectrometry and Sample Preparation Strategies for Candidate Biomarkers Identification and Quantification
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Lecture 9:
Pushing the Sensitivity Limits of Mass Spec for Discovery Biomarkers Quantification in Non-Liquid Matrices by Novel Sample Preparation, Chromatography and Instrumentations
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Lecture 10:
Strategies for the Quantification of Fecal Biomarkers for Inflammatory Bowel Disease (IBD) by Mass Spectrometry
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Lecture 11:
Mass Spectrometry Advanced Application for Ophthalmology Molecules and Challenges in Multiple Ocular Matrices
Part 4: Novel Applications in Bioanalysis
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Lecture 12:
Recent Developments in Quantitative Bioanalysis of Protein Panel by Mass Spectrometry: What are the Acceptance Criteria and Regulatory Requirements for Targeted Proteomics?
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Lecture 13:
Complex Mass Spec Development, Validation and Method Transfer of Total Lipid and Multiple Isoforms Biomarkers
Part 5: White Paper in Bioanalysis
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2022 White Paper on Biomarker Topics:
Consensus & Conclusions on Mass Spectrometry Bioanalysis Topics for 2022 White Paper
