"Mass Spectrometry Novel Technologies, Novel Modalities, and Novel Challenges"
New Tools to Reach Max Sensitivity & Selectivity; Advanced Applications in Column Chemistry and Separations Techniques; Problem Solving for Novel Modalities, Non-Liquid and Rare Matrices Method Development/Validation
Part 1: Novel Technologies
Myths and Realities in the Use of HILIC to Replace Ion-Pairing and Hexafluoroisopranol (HFIP) for Oligonucleotides Bioanalysis: Does it really work? Is it possible to reproduce the published results? Is sensitivity still a limitation with HILIC approaches?
Use of Aptamers as a Novel Reagent in Regulated Bioanalysis for Large Molecule Quantification by Hybrid Assays (IA-MS): Advantaged and Disadvantages in using Aptamers in Immunoaffinity enrichment
EAD vs CID Fragmentation for Small Molecule and their Metabolites: Is EAD Technology going to replace CID or do we still need both?
Part 2: Novel Modalities & Novel Method Development/Validation Challenges
Lectures 4, 5:
Novel/Advanced Strategies and Recent Advancements in ADC Bioanalysis by Mass Spectrometry
- Selecting the right Internal Standard - Lecture 4
- Method Development approaches for Biotransformation - Lecture 5
Lectures 6, 7:
Novel/Advanced Strategies and Recent Advancements in RNAi and ASO Therapeutics Bioanalysis by Mass Spectrometry
- HRMS Method Development approaches for Metabolism/Biotransformation - Lecture 6
- Advantages of Hybridization Mass Spec vs “gold standard” Hybridization LBA - Lecture 7
Part 3: Problem Solving for Non-Liquid and Rare Matrices
Peripheral Blood Mononuclear Cell (PBMC) by Mass Spectrometry and Sample Preparation Strategies for Candidate Biomarkers Identification and Quantification
Pushing the Sensitivity Limits of Mass Spec for Discovery Biomarkers Quantification in Non-Liquid Matrices by Novel Sample Preparation, Chromatography and Instrumentations
Strategies for the Quantification of Fecal Biomarkers for Inflammatory Bowel Disease (IBD) by Mass Spectrometry
Mass Spectrometry Advanced Application for Ophthalmology Molecules and Challenges in Multiple Ocular Matrices
Part 4: Novel Applications in Bioanalysis
Recent Developments in Quantitative Bioanalysis of Protein Panel by Mass Spectrometry: What are the Acceptance Criteria and Regulatory Requirements for Targeted Proteomics?
Complex Mass Spec Development, Validation and Method Transfer of Total Lipid and Multiple Isoforms Biomarkers
Part 5: White Paper in Bioanalysis
2022 White Paper on Biomarker Topics:
Consensus & Conclusions on Mass Spectrometry Bioanalysis Topics for 2022 White Paper